烟台毓璜顶医院

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网站备案:鲁ICP备05035890号

 

 

鉴定专家

刘雪霞

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简 介
国家司法鉴定人,鉴定室副主任,硕士,副主任技师,山东省干细胞工程技术研究中心副主任,硕士研究生导师。
 
擅长
法医遗传标记,法医STR分型,亲子鉴定,司法亲权鉴定,亲缘关系鉴定等。
 

教育背景

1.1994/09-1999/07,青岛大学医学院,临床医学,学士

2.1999/09-2002/07,青岛大学医学院,医学遗传学,硕士

 

承担项目情况

1.山东省自然科学基金,ZR201911040212,男性生殖关键分子CMTM4影响精子质量的分子基础研究,2020/07-2023/06,在研,主持。
2.国家自然科学基金,81971438,睾丸特异性蛋白CMTM2参与精子发生、精子质量调控的功能及机制研究,2020/01-2023/12,55万,在研,参与。
3.山东省自然科学基金,ZR2019MH035,睾丸特异表达基因Cmtm2b敲除致雄性不育的功能研究,2019/07-2022/06,20万,在研,参与。
4.山东省重点研发计划,2018GSF118055,E2F家族SNP及相关血清miRNA与咽喉癌进展的相关性研究,2018/01-2019/12,12万元,结题,参与。
5.国家自然科学基金(应急项目),81370013,调节性T细胞自噬异常在原因不明复发性流产发病机制中的作用,2018/01-2018/12,20万元,结题,参与。
6.烟台市科技计划,2015WS002,基于人附睾液微环境的精子成熟关键蛋白筛选,2015/01-2017/12,3万元,结题,主持。
7.山东省自然科学基金,2013ZRA06005,人类附睾高表达PATE蛋白调节CHRNA7活性促进精子顶体反应的机制研究,2013/01-2015/12,8万元,结题,参与。
8.烟台市重大攻关项目,2009107,建立人体细胞克隆胚胎干细胞系,2009/01-2012/12,70万元,结题,参与。
9.国家科技部(973计划项目),2005CB522705-2,组织工程学重要基础科学问题研究-同种异体干细胞研究与通用胚胎干细胞库的建立,2005/01-2010/12,100万元,结题,参与。
10.国家科技部(863计划重大专项),2003AA205008,人胚胎干细胞定向诱导造血干细胞分化及其移植治疗研究,2004/01-2006/12,144万元,结题,参与。

学术论文

1. XueXia LiuZhiXin WangFuJun Liu. Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice. Chemosphere.2021 Jan;262:127880.

2. FuJun Liu, XueXia Liu, Xin Liu, Ting Li, Peng Zhu, ZhengYang Liu, Hui Xue, WenJuan Wang, XiuLan Yang, Juan Liu, WenLing Han. Integrated Analyses of Phenotype and Quantitative Proteome of CMTM4 Deficient Mice Reveal Its Association With Male Fertility, Mol Cell Proteomics. 2019 Jun;18(6):1070-1084.  

3. Liu Xue-Xia#, Zhang Hua#, Shen Xiao-Fang, Liu Fu-Jun*, Liu Juan, Wang Wen-Juan. Characteristics of testis-specific phosphoglycerate kinase 2 and its association with human sperm quality, Human Reproduction, 2016, 31:273-279.

4. Liu XueXia, Wang Xiong, Liu FuJun*. Decreased expression of heat shock protein A4L in spermatozoa is positively related to poor human sperm quality, Molecular Reproduction and Developmnet, 2019, 86: 379-386.

5. Liu Xuexia#, Li Qian#, Wang Wenjuan., Liu Fujun*. Aberrant expression of sperm‑specific glycolytic enzymes are associated with poor sperm quality, Molecular Medicine Reports, 2019, 19: 2471-2478.

6. Liu Xuexia#, Cai Li#, Liu Fujun*. An in silico analysis of human sperm genes associated with asthenozoospermia and its implication in male infertility, Medicine, 2018, 97: e13338.

7. Xuexia LiuFujun Liu. In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa. Mol Med Rep.2015 Jul;12(1):173-9.

8. Xue Xia LiuXiao Fang Shen, Fu-Jun Liu. Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality Mol Med Rep.2016 Aug;14(2):1594-600.

9. Yuan Y, Zhang H, Liu X, Lu Z, Li G, Lu M, Tao X. MicroRNA signatures predict prognosis of patients with glioblastoma multiforme through the Cancer Genome Atlas.  Oncotarget.2017 Apr 6;8(35):58386-58393.

10. Hua ZhangXuexia LiuLei ChenLi CaiNing LiPeng ZhuJian ChenXicheng SongGuojun Li. Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma

Oncotarget.2017 Jan 10;8(2):3471-3480.

11. Jing LiuXuexia LiuLi CaiJie XueChunjuan SunZhiling MuAimin Li. Cardiac magnetic resonance evaluation of left ventricular functional, morphological, and structural features in children and adolescents vs. young adults with isolated left ventricular non-compaction. Int J Cardiol.2018 Nov 15;271:402.

12. Jianyuan Li  1 Xuexia LiuHaiyan WangShouxin ZhangFujun LiuXuebo WangYanwei Wang. Human embryos derived by somatic cell nuclear transfer using an alternative enucleation approach. Cloning Stem Cells.2009 Mar;11(1):39-50.

13. Xin LiuShao-Hua JinXue-Xia LiuWen-Juan WangFu-Jun Liu. Proteome profiling of the sperm maturation milieu in the rhesus monkey (Macaca mulatta) epididymis. Reprod Fertil Dev.2016 Apr;28(6):732-41.

14. Fu-Jun LiuXin LiuJun-Ling HanYan-Wei WangShao-Hua JinXue-Xia LiuJuan LiuWen-Ting WangWen-Juan Wang. Aged men share the sperm protein PATE1 defect with young asthenozoospermia patients. Hum Reprod 2015 Apr;30(4):861-9.

15. Xin LiuFu-Jun LiuShao-Hua JinYan-Wei WangXue-Xia LiuPeng ZhuWen-Ting WangJuan LiuWen-Juan Wang. Comparative proteome analysis of human testis from newborn, young adult, and aged men identified spermatogenesis-associated proteins. Electrophoresis 2015 Jun 1.

16. Kai WangNing LiChing-Hei YeungTrevor G CooperXue-Xia LiuJuan LiuWen-Ting WangYan LiHui ShiFu-Jun Liu. Comparison of gene expression of the oncogenic Wnt/β-catenin signaling pathway components in the mouse and human epididymis. Asian J Androl Nov-Dec 2015;17(6):1006-11.

17. Juan LiuCheng T RongYan LiXue X LiuWen T WangNing Li. Vasectomy induces oxidative stress and up-regulates the expression of peroxiredoxins in mouse testis in short and early periods after surgery. J Urol.2014 Jun;191(6):1920-6.

荣誉奖项

1.烟台市科技进步奖-三等奖 PGK2在人精子质量评价中的应用。(第一位)

专利著作

1.实用新型专利:一种医用检验支架;刘雪霞,张华

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